Effects of flavonoids on reducing Aβ deposition and Tau hyperphosphorylation in Alzheimer's disease
Alzheimer's disease(AD)is the most prevalent neurodegenerative disorder.From a neuropathological point of view,AD is characterized by the deposited senile plaques mainly formed by aggregates of amyloid β-protein(Aβ)and neurofibrillary tangles(NFTs)formed by Tau protein hyperpho-sphorylation.Flavonoids are polyphenolic compounds spotted in various fruits and vegetables,mainly in six categories.Many studies have confirmed that a variety of flavonoids can reduce Aβ deposition and/or inhibit Tau protein hyperphosphorylation.This review mainly describes these two main pathological features of AD and the mechanism by which flavonoids act on them.
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