The regulatory role of exosomal circRNA in the tumor microenvironment
The tumor microenvironment is the surrounding internal environment on which tumor cells depend and has been shown to be a key factor influencing tumor cell proliferation,metastasis and immune evasion and chemoradiotherapy.Exosomal circRNAs can play an important regulatory role in the development of tumor proliferation,dissemination,and drug resistance by recruiting and activating important constituent cells of the tumor microenvironment,such as tumor cells,fibroblasts,macrophages,lymphocytes,endothelial cells,and natural killer cells,to remodel the tumor's own microenvironment.This paper reviews the mechanism of exosomal circRNAs from tumor and tumor stromal cells to promote tumor metastasis and chemoresistance,and the advantages and application prospects of exosomal circRNAs as tumor biomarkers and therapeutic tools for clinical treatment from the perspective of tumor microenvironment regulation by exosomal circRNAs from different cell sources.
万方数据
维普
