Yeast and lipopolysaccharide induce different febrile responses in mice
Fungal infection is always associated with prolonged and low-grade fever,while bacterial infection results in either fever or hypothermia.However,the cause of differential pyrogenic manifestations between fungi and bacteria remains elusive.In this study,yeast and lipopolysaccharide(LPS)were used to establish fever models in mice,the pyrogenetic activity between baker yeast and lipopolysaccharide,and the activation of the preoptic area of hypothalamus(POA)neurons are observed via different temperature measurement approaches(rectal thermometer,infrared thermometer,abdominal telemetry)and different ambient temperatures(30 oC,26 oC,22 oC).The results show that yeast infection produces a robust febrile response independent of changes in ambient temperature and insensitive to experimental stimuli;yeast and LPS activate different POA neurons respectively,yeast and LPS-induced fever are associated with the ventromedial preoptic area(VMPO),while the medial preoptic area(MPO)is associated with LPS-induced hypothermia.These results provide a preliminary basis for further elucidating the mechanism of different febrile reactions induced by fungi and bacteria.
bacterial feverfungal feverlipopolysaccharideyeastambient temperaturepreoptic area of hypothalamusinfrared thermometry
万方数据
维普
