Roles of acetylcholine signaling pathway in lung cancer
Lung cancer is one of the most fatal diseases in the world today,which seriously threatens human life and health.The neurotransmitter acetylcholine(ACh)acts as an autocrine and paracrine growth factor for human lung cancer,which binds to nicotinic acetylcholine receptors(nAChRs)and muscarinic acetylcholine receptors(mAChRs)to accelerate lung cancer cell proliferation,migration and invasion.In recent years,genome-wide data studies have shown that nAChRs are closely related to the smoking-related risk of lung cancer.Therefore,the study of nAChRs is significant in the development of drugs for the treatment of lung cancer.This work reviews the mechanism of acetylcholine signaling pathway in lung cancer progression,which provides a basis for its development as a new molecular drug-target for lung cancer treatment.
acetylcholine signaling pathwaynicotinic acetylcholine receptormuscarinic acetylcholine receptorlung cancer