Advances in nomenclature for chordate olfactory receptor genes
Olfactory receptors are members of the G protein-coupled receptor family,playing a crucial role throughout the entire lifespan of chordates.Distinguished from most gene families,the olfactory receptor family is a vast superfamily consisting of a large number of members.Providing logical names for these receptors enables better description,analysis,and discussion of the family.Additionally,it offers semantic information that assists machine learning programs in automatically constructing the corresponding protein structure and functional knowledge bases from extensive olfactory receptor databases.However,naming olfactory receptor genes appropriately poses significant challenges,given the rapid evolution,the large number of genes,a high incidence of pseudogenes,and substantial variations in their distribution across species and chromosomes in chordates.Over the past three decades,the field of olfactory receptor research has experienced significant development,resulting in several iterations of olfactory receptor gene nomenclature,all of which have played a positive role at its respective stage.The advancement of sequencing technologies and bioinformatics algorithms tools has brought about a massive influx of newly annotated olfactory receptor genes.This overwhelming number has rendered the existing olfactory receptor gene nomenclature increasingly inadequate to accommodate the needs of big data mining and knowledge engineering system development.Consequently,there is an urgent need for a new olfactory receptor gene nomenclature that can satisfy current demands.
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