摘要
脂氧合酶是一种含铁的氧化还原酶,存在于动植物的组织和细胞中.脂氧合酶主要分为1、3、5、8、12、15-脂氧合酶6种亚型.5-脂氧合酶(5-lipoxygenase,5-LOX)是LOX同工酶中研究较为深入的非血红素铁蛋白氧化代谢酶,是许多高活性氧化脂质生物合成中的关键酶,参与多种炎症性疾病,如炎症、哮喘、脑缺血、部分恶性肿瘤及阿尔茨海默症等疾病的发生和发展过程.因此,开发有效的5-LOX抑制剂对治疗上述疾病至关重要.本文介绍了5-LOX抑制剂的研究成果,并对其分类、来源、治疗药效和优缺点进行了讨论,为深入研发创新型5-LOX抑制剂提供理论依据.
Abstract
Lipoxygenases are an iron-containing oxidoreductases which found in the tissues and cells of plants and animals.Lipoxygenases are mainly divided into 6 subtypes of 1,3,5,8,12 and 15-lipoxygenase.5-lipoxygenase(5-LOX)is a non-heme ferritin oxidative metabolic enzyme which has been studied deeply among LOX isoenzymes,and it is a key enzyme in the biosynthesis of many highly active oxidative lipids.The key role of the 5-lipoxygenase in formation of inflammation,asthma,cerebral ischemia,some malignant tumors and Alzheimer's disease had been demonstrated.Therefore,the development of effective 5-LOX inhibitors is crucial for the treatment of these diseases.This article,reviews the research findings introducing 5-LOX inhibitors,by focusing on the classification,and discusses on their sources,therapeutic efficacy,advantages and disadvantages of them.It can provide a theoretical basis for further research and development of innovative 5-LOX inhibitors.
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