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鼻咽癌的免疫与靶向治疗

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鼻咽癌的发生与EB病毒(Epstein-Barr virus,EBV)密切相关,当前临床主要运用单纯放疗或同步放化疗对鼻咽癌开展治疗.虽然该方法对放化疗敏感的患者有效,但是局部晚期或远处转移的鼻咽癌患者预后仍然不佳.随着近年来免疫治疗和分子靶向治疗的发展,过继性细胞疗法、免疫检查点以及多分子靶向治疗逐渐成为鼻咽癌临床治疗的研究热点.本文就鼻咽癌的免疫治疗和靶向治疗两方面展开综述,以期为鼻咽癌治疗手段和药物的发展提供一定依据.
Immune and targeted therapy for nasopharyngeal carcinoma
Nasopharyngeal carcinoma is closely related to Epstein-Barr virus(EBV)and is currently clinically treated with radiotherapy alone or concurrent radiotherapy.Although this approach is effective in patients who are sensitive to radiotherapy,the prognosis for patients with locally advanced or distant metastatic nasopharyngeal cancer remains poor.With the development of immunotherapy and molecular targeting therapy in recent years,peripatetic cell therapy,immune checkpoints and multi-molecular targets and pathways have gradually become hot spots in the clinical treatment of nasopharyngeal carcinoma.This paper reviews the immunotherapy and targeted therapy for nasopharyngeal carcinoma,with a view to provide a basis for the development of therapeutic tools and drugs for nasopharyngeal carcinoma.

nasopharyngeal carcinomaEpstein-Barr virusimmunotherapymolecularly targeted therapy

闫杰成、彭玲巧、庄佳丰、黄静

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广东医科大学附属医院肿瘤科,湛江 510095

鼻咽癌 Epstein-Barr病毒 免疫治疗 分子靶向治疗

2023

生命的化学
中国生物化学与分子生物学会

生命的化学

CSTPCD
影响因子:0.404
ISSN:1000-1336
年,卷(期):2023.43(5)
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