Aging in human is a complex physiological process in which the organism undergoes degenerative changes in physiological structure with age,as well as functional decline,showing reduced organismal fitness and resistance.The immune system is the main regulatory system of the aging process,and immunosenescence also leads to a reduced ability of the body to resist pathogens and cancer cells,accompanied by the occurrence of related diseases,such as cardiovascular diseases,neurological diseases,and cancer.This review focuses on immunosenescence and the recent advances in understanding the role of immune cells in aging,aiming to elucidate the relationship between immunosenescence and aging related diseases and the mechanisms of immune cell anti-aging,so as to provide a new strategy for precision immune cell anti-aging modalities with clinical applications.
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