首页|感染性疾病的分子诊断新方法及临床应用

感染性疾病的分子诊断新方法及临床应用

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感染性疾病仍是危害人类健康的主要问题之一,并可能造成暴发性流行性疾病,给全球卫生系统带来了极大的疾病负担.病原学的明确诊断是感染性疾病精准诊疗的先决条件,由于已知病原体的变异、新发病原体的不断出现以及机会性致病菌的增加,临床诊疗工作面临巨大挑战.然而传统的分离、培养方法作为病原学诊断的金标准,培养周期长、敏感性低且污染率高,这促使分子诊断技术向快速、高效、自动化、数字化不断发展,并发挥了越来越大的作用.本文主要综述了近年来新的分子诊断方法在感染性疾病中的临床应用及面临的挑战.
New molecular methods and clinical application in the diagnosis of infectious diseases
Infectious diseases are the main cause of morbidity and death in patients around world,and may cause fulminant epidemic diseases,bringing a great burden to the global health system.A definite diagnosis of etiology is a prerequisite for the accurate diagnosis and treatment of infectious diseases.With the variation of known pathogens,the continuous emergence of new pathogens and the increase of opportunistic pathogens,clinicians and scientists are facing growing diagnostic and therapuetic challenges in the field of infectious diseases now.However,as the traditional gold standard for pathogen diagnosis,the traditional isolation and culture methods are considered time-consuming,less sensitive and high risks of pollution contamination,necessitating the development of molecular diagnostic technology to be rapid,efficient,automated and digitalized,which is playing more and more important role.This work mainly focuses on the clinical application and challenges of new molecular diagnostic methods in infectious diseases in recent years.

molecular diagnostic techniquesinfectious diseasespathogenic microorganisms

欧静、吴桐、董晗、刘琳、张湘燕

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遵义医科大学第一临床医学院呼吸与危重症医学科,遵义 563000

贵州省人民医院呼吸与危重症医学科,贵阳 550000

国家卫生健康委员会肺脏免疫性疾病重点实验室,贵阳 550000

分子诊断技术 感染性疾病 病原微生物

贵州省卫健委科学技术项目贵州省卫健委科学技术项目

gzwkj2021-088黔科合基础-ZK[2022]一般254

2023

生命的化学
中国生物化学与分子生物学会

生命的化学

CSTPCD
影响因子:0.404
ISSN:1000-1336
年,卷(期):2023.43(5)
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