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蜜蜂蜂毒过敏的免疫机制及治疗进展

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我国山地森林面积覆盖大、膜翅目昆虫种类繁多,每年被蜂蛰伤的人很多.蜇伤后一般只会有轻微的局部反应,但对蜜蜂毒液过敏者有可能发生全身过敏反应,严重者甚至危及生命.蜜蜂蜇伤过敏国外早已开始免疫治疗,而国内蜜蜂蜇伤过敏目前主要是对症支持治疗,对于蜜蜂毒液过敏者的免疫治疗研究甚少,缺乏对蜜蜂蜇伤过敏的系统性认识.本文介绍了蜜蜂蜇伤毒液过敏的流行病学、免疫损伤机制,并重点对免疫治疗的适用人群、治疗机制、治疗方案、效果及不良反应展开介绍,为蜜蜂蜇伤蜂毒过敏患者提供新的治疗和预防策略.
Research progress in immunologic mechanisms and therapies of bee venom allergy
The mountainous forests of our country cover a large area and have a wide variety of hymenopteran species,which caused mamy people be stung by bees every year.Bee stings usually will only receive a slight local reaction,but people allergic to bee venom may occur systemic allergic reaction,and even life-threatening.Immunotherapy for bee sting allergy has been started abroad for a long time,but at present,bee stings and allergies in China mainly rely on symptomatic support and treatment.The immunotherapy research for bee venom allergy is very little,and the systematic understanding of bee sting allergy is lacking.This paper introduces the epidemiology and immune injury mechanism of bee sting venom allergy,and focuses on the applicable population,treatment mechanism,treatment scheme,effect and adverse reactions of immunotherapy,so as to provide new treatment and prevention strategies for patients with bee sting venom allergy.

bee venomallergic reactionimmunologic mechanismvenom immunotherapy

李文来、李玥、李轩维、马聪媛、朱平

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三峡大学第一临床医学院,宜昌市中心人民医院肾内科,宜昌 443002

三峡大学第二临床医学院,三峡大学附属仁和医院内分泌科,宜昌 443001

蜂毒 过敏反应 免疫机制 免疫治疗

湖北省教育厅科学研究计划指导项目湖北省宜昌市医疗卫生研究资助项目

B2017024A20-2-002

2023

生命的化学
中国生物化学与分子生物学会

生命的化学

CSTPCD
影响因子:0.404
ISSN:1000-1336
年,卷(期):2023.43(5)
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