Valproic acid(VPA),a branched short-chain fatty acid,is an antiepileptic drug.Valproic acid is mainly used for epilepsy,but also for bipolar disorder and migraine.It has neuroprotective effect.However,prenatal exposure to valproic acid increases the risk of congenital malformations,autism,and neural tube defects of children.Valproic acid has toxic effects on the neurodevelopment of offspring,but its specific mechanism is still unclear.At present,many studies have found that valproic acid can affect different brain regions of offspring and change multiple pathways in brain regions.This article reviewed the current research progress on the effects of valproic acid on neurodevelopment,and discussed the underlying mechanisms and related factors of these effects on valproic acid.
valproic acidprenatal exposureneurodevelopmentbrain regions
万方数据
维普
