Roles of glomerular endothelial-to-mesenchymal transition for renal fibrosis in diabetic kidney disease
Renal fibrosis is an important pathological feature of diabetic kidney disease(DKD).In recent years,several studies have shown that glomerular endothelial-to-mesenchymal transition(EndoMT)can promote renal fibrosis and play an important role in the development of DKD,but its specific mechanism still needs to be studied.This paper reviews the molecular mechanism of EndoMT in renal fibrosis of DKD and the current research progress on delaying renal fibrosis of DKD by anti-EndoMT therapy,in order to provide a new theoretical basis for the clinical treatment of DKD.
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