Neutrophil extracellular traps(NETs)are a kind of fibrous network complex released by neutrophils outside the cell under the influence of special factors.Under the induction of viruses,cytokines,activated platelets,complement,autoantibodies and other factors,specific neutrophil subsets produce and release NETs,which play a variety of roles in the body and participate in the development of cardiovascular diseases,metabolic diseases,autoimmune diseases and other diseases.It is also closely related to related non-infectious pathological processes such as coagulopathy,thrombosis,atherosclerosis,vasculitis and so on.Therefore,controlling the occurrence and development of NETs in related diseases may be a potential therapeutic target.This paper summarizes the effects of NETs in metabolic diseases,tumors,novel coronavirus infection and other related diseases,discusses the clinical application of anti-NETs drugs,and provides new ideas for clinical drug selection and application.
关键词
中性粒细胞胞外诱捕网/肿瘤/新型冠状病毒感染/非感染性病理过程
Key words
neutrophil extracellular traps/tumor/novel coronavirus infection/non-infectious pathological process
维普
万方数据