Research progress of ferroptosis in the treatment of leukemia
Ferroptosis is a novel cell death mode involving in specific lipid peroxidation and pathways mediated by iron ions.The dysregulation of iron homeostasis,imbalance of lipid metabolism and accumulation of reactive oxygen species in leukemia cells are consistent with the basic mechanism of ferroptosis and provide a theoretical rationale for the induction of ferroptosis in leukemia.This review summarized the progress of research on ferroptosis in the treatment of different types of leukemia and discussed the mechanisms of action of the relevant drugs,which may provide novel therapeutic targets for leukemia.
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