Effects of photoperiod on lipid metabolism in rodents
Obesity and related metabolic diseases have become widespread worldwide,and numerous studies have shown that rodents can serve as ideal models for studying lipid-related metabolic diseases in humans.Animals have evolved the ability to anticipate changes in their external environment in order to adjust their physiology and behavior in preparation for the energy demands of the changing seasons.In small rodents,they through periodic changes in food intake and energy expenditure to achieve seasonal changes in fat and body weight,and prepare for the energy needs of the seasons.These long-term changes in energy balance are not simply influenced by the brain centers,but are also regulated by hormones.This paper reviews the neuroendocrine pathway mediated by photoperiod energy metabolism and the molecular mechanisms of leptin and melatonin regulating body weight and lipid metabolism.
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