Circadian clock genes and disorders of lipid metabolism
The biological clock is a special physiological mechanism formed by organisms adapting to changes in environmental rhythms,and has a certain rhythm.The circadian clock gene has been shown to be involved in the regulation of biological physiological activities,for example,various metabolic activities of organisms,apoptosis and necrosis of cells,occurrence and development of tumors,inflammatory reactions and so on.Lipid metabolism is an important metabolic activity in biology,the disorder of lipid metabolism may induce hyperlipidemia,atherosclerosis and other diseases.A growing number of research shows that lipid metabolism is regulated by genes associated with the circadian clock.This work reviews the physiological mechanism of the circadian clock and the involvement of circadian clock genes in the regulation of lipid metabolism.
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