首页|外泌体糖基化在疾病诊断及治疗中的应用

外泌体糖基化在疾病诊断及治疗中的应用

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外泌体由脂质双分子层构成,内含多种生物分子,如蛋白质、核酸、糖类等,具有调节生命活动的作用,其蛋白质组分也可反映分泌细胞状态.糖基化是一种常见的蛋白质翻译后修饰形式,糖基化蛋白对于维持细胞稳态、细胞间互作等生理功能具有重要作用.近年来,有关于外泌体的研究大多关注外泌体核酸成分如miRNA、mRNA、lncRNA等的功能.外泌体膜蛋白也含有丰富的糖链,且具有重要的病理生理意义.本文着重介绍外泌体糖基化的结构、研究方法、在肿瘤等疾病中的分子功能以及在疾病诊断、治疗中的临床应用和前景.外泌体糖基化研究将随着技术的革新不断深入,有望成为多种疾病临床诊疗的重要手段.
Glycosylation of exosomal proteins in disease diagnosis and treatment
Exosomes are composed of lipid bilayers containing a variety of biomolecules,such as proteins,nucleic acids and glycans,which have a role in regulating life activities,and their protein fractions may also reflect the secretory cell state.Glycosylation is a common form of post-translational modification of proteins,and glycosylated proteins have important roles in maintaining cellular homeostasis,intercellular interactions and other physiological functions.In recent years,there are studies on exosomes mostly focusing on the functions of exosomal nucleic acid components such as miRNA,mRNA,and lncRNA.It has been found that exosomal membrane proteins are also rich in glycosyl chains and have important pathophysiological significance.This paper focuses on the structure,research methods of exosomal glycosylation,and its molecular functions in diseases such as tumors,and its clinical applications in disease diagnosis and treatment.The study of exosomal glycosylation will continue to progress with the innovation of technology and is expected to become an important tool for clinical diagnosis and treatment of many diseases.

exosomeglycosylationdiseases

吴祎凡、李锐、蒋锐、宋昕烨、杨帆、刘静芸、秦棪楠

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西安交通大学医学部,西安 710061

西安交通大学基础医学院细胞生物学与遗传学系,西安 710061

外泌体 糖基化 疾病

国家自然科学基金

81401137

2023

生命的化学
中国生物化学与分子生物学会

生命的化学

CSTPCD
影响因子:0.404
ISSN:1000-1336
年,卷(期):2023.43(6)
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