Expression and mechanism of Lp(a)in diabetic vascular complications
The prevalence of type 2 diabetes is increasing every year and diabetic vasculopathy is one of the major chronic complications,which is an important cause of high mortality and disability in diabetes.Lipoprotein(a)[Lp(a)]was found to be an effective predictor and risk factor for type 2 diabetes and vascular complications,and is involved in the process of insulin resistance and abnormal lipid metabolism through mechanisms such as promoting atherosclerosis,promoting thrombosis,anti-angiogenesis,inducing inflamma-tion and oxidative stress.This paper aims to review the expression and mechanism of Lp(a)in diabetic vascular complications,with a view to improving its clinical application.
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