Nucleic acid deaminases are zinc-dependent enzymes that can deaminate cytosine or adenine in both DNA and RNA substrates,and therefore induce conversion of the base.The deaminases play important roles in the regulation of immune and nervous system in organisms,and several of them have been developed into precise and efficient base editors.This paper reviews the structure,function and evolution of nucleic acid deaminases,which will shed more light on the research and application of deaminases.
关键词
胞苷脱氨酶/腺苷脱氨酶/胞嘧啶单碱基编辑器/腺嘌呤单碱基编辑器/进化
Key words
cytidine deaminase/adenosine deaminase/cytosine base editor/adenine base editor/evolution
维普
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