Alzheimer's disease is a neurodegenerative disease with progressive cognitive impairment as its clinical manifestation,and the specific pathogenesis is still unclear.Gut microbiota imbalance is closely related to the occurrence of AD and plays an important role in the occurrence and development of AD.Gut microbiota can communicate with the central nervous system through neural,endocrine and immune channels,and may cause neurodegenerative diseases by producing harmful substances,secreting or regulating neurotransmitters,inducing neuroinflammation.This paper aims to provide a new research directions for the prevention and treatment of AD by summarizing the relationship between intestinal flora and cognition at different ages and analyzing the correlation between gut microbiota and the pathogenesis of AD.
维普
万方数据