Marine environment is complex and changeable,and its undeveloped habitats contain abundant and precious biological resources,which are high salt,high pressure,oligotrophic,perennial high or low temperature,etc.Marine microorganisms have developed unique metabolic mechanisms to adapt to special ecological environment of the ocean after a long period of continuous slow evolution,which greatly increases the possibility of discovering new active substances.Marine microbial metabolites are considered as potential sources for discovering new naturally active compounds(new quorum sensing inhibitors).In this review,we firstly introduce concept and origin of quorum sensing,and then discuss different kinds of quorum sensing,and introduce concept and classification of quorum sensing inhibitors,and finally summarize progress of quorum sensing inhibitors from marine microorganisms.It will lay the foundation for further researching on quorum sensing inhibitors and provide new ideas for the development of novel drug against pathogen infections.
关键词
群体感应/群体感应抑制剂/海洋微生物/信号分子/应用
Key words
quorum sensing/quorum sensing inhibitors/marine microorganisms/signal molecules/applications
维普
万方数据