胰岛素样生长因子2 mRNA结合蛋白2(insulin growth factor 2 mRNA binding protein 2,IGF2BP2)是一种调节多种生物过程的RNA结合蛋白,最初作为2型糖尿病的相关基因被发现,随着深入的研究,人们发现它在多种肿瘤的发生发展中也起着重要的生物学作用.IGF2BP2可以作为一种m6A阅读器,通过与不同的非编码RNA(如miRNAs、lncRNAs和circRNAs)相互作用参与癌症的发生发展.本次综述总结了IGF2BP2在多种癌症中的生物学作用、机制以及预后潜力,以期为癌症的诊断及预后提供新的标志物,同时为IGF2BP2作为癌症精准化治疗靶点的相关研究提供新的思路.
Abstract
Insulin growth factor 2 mRNA binding protein 2(IGF2BP2)is an RNA-binding protein that regulates a variety of biological processes.Initially,IGF2BP2 was discovered as a gene related to type 2 diabetes,and with further research,it was found that IGF2BP2 also plays an important biological role in the development of a variety of tumors.IGF2BP2 is an m6A reader involved in cancer development by interacting with different noncoding RNAs such as miRNAs,lncRNAs,and circRNAs.This review summarizes the biological function,mechanism and prognostic potential of IGF2BP2 in a variety of cancers,in order to provide new markers for the diagnosis and prognosis of cancer,and to provide new ideas for IGF2BP2 as a target for precision cancer treatment.
维普
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