Research progress of CD137+ T cells effector function
CD137+(also named 4-1BB;tumor necrosis factor receptor superfamily 9,TNFRSF9)T cells are antigen-specific activated effector cells.CD137+ T cells have a strong ability to proliferate and produce cytotoxic effector factors after antigen stimulation,enabling them to play an immunomodulatory role in various diseases.Among these CD137+ T cells,the soluble CD137 protein secreted by CD137+ regulatory T cells has a potent anti-inflammatory effect.Therefore,a comprehensive understanding of the role of CD137+ T cells in disease is essential to develope effective disease immune prevention strategies.This review focuses on the regulatory mechanism of CD137-related signals on the function of T cells,especially CD8+ T cells,the characteristics and effector functions of CD137+ T cells,and the immunoregulatory role of CD137+ T cells in the progression of various diseases.This review aims to provide implications for the immunotherapy of CD137+ T cells in the future.
CD137+ T cellsantigen-specific T cellsimmune microenvironmentsimmune therapy
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