Voltage-gated sodium channels are transmembrane sodium channel proteins whose gated state is controlled by the difference in electrical potential between the inside and outside of the cell membrane,and which can only be activated and opened by depolarising membrane voltage.Nav1.4 is highly expressed in a skeletal muscle and mainly forms the ascending action potential branch,which is involved in a range of skeletal muscle-related physiopathological action activities in the body.Sodium channel blockers and activators are two classes of drugs used to treat sodium channel disorders in the cardiovascular system,and it is important to have an in-depth and comprehensive understanding of them.In this paper,from the aspects of Nav1.4 molecular structure,function,drug development,and so on,the regulatory mechanism of Nav1.4,related diseases,and the research of highly selective drugs are briefly reviewed,which lays a certain theoretical basis for the development of drugs based on Nav1.4 as a target.
Nav1.4Nav1.4 selective inhibitorion channel diseasetarget drug
万方数据
维普
