Research process and mechanisms of cellular sensing of matrix mechanical signals
With the advancement of cellular mechanics and in-depth investigations into the field of cellular mechanobiology,the crucial role of mechanical signals in the extracellular matrix(ECM)has gradually emerged in processes such as cell adhesion,proliferation,differentiation,and apoptosis.Cells perceive matrix mechanical signals through the interaction between adhesion proteins on the cell membrane and adhesive ligands within the matrix,subsequently regulating cellular mechanotransduction.This ultimately leads to changes in nuclear mechanics,thereby governing vital cellular activities including migration,tissue formation,and cancer development.In this paper,we provide a comprehensive overview of the development of cellular mechanics in biology,elucidate the interplay between cells and their microenvironment,and delve into the intricate processes and mechanisms of cellular mechanotransduction.
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