Cytoplasmic phospholipase A2 and mechanical signal transduction
Cells possess the remarkable capacity to assess and interpret their surrounding microenvironment.The behavior of cells is intimately intertwined with the influence exerted by this microenvironment.However,the precise mechanisms through which various environmental factors impact cells remain largely unknown.In recent years,numerous investigations have postulated that the nucleus plays a pivotal role in its perceptual capabilities.This paper reviews the functional role of a recently identified nuclear mechanical sensor known as cytoplasmic phospholipase A2(cPLA2).Remarkably,cPLA2 exhibits the ability to detect diverse forms of mechanical stimuli,is capable of translocating to the nuclear membrane,and subsequently activates distinct downstream signaling pathways,thereby modulating various cellular functions.A comprehensive under-standing of cPLA2 paves the way for novel avenues of exploration into the nucleus′ ability to perceive mechanical signals.
万方数据
维普
