Integrins are transmembrane adhesion molecules expressed ubiquitously on cell surface,which regulate various physiological processes including cell adhesion,migration,survival,immune surveillance,thrombosis,and development through signal transduction by sensing intracellular and extracellular stimulation.Integrins usually exist in an inactive conformation on the cell surface,but can be change to an extended active conformation regulated by inside-out and outside-in signaling.The transformation of integrin activation state is closely related to its internalization and recycling process as well as the normal physiological cell activity.Many diseases are associated with the deregulation of integrin activity.The normal function of integrin is the result of the balance between activation and inactivation.Here,we discuss the dynamic transformation of integrin activity during cell migration and disease development,and we also review the integrin-inactivating proteins.
维普
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