Regulation of cytoskeleton intermediate filaments vimentin on macrophage
Macrophages are one of the important type of phagocytic cells in innate immunity that participate in pathogen clearance,regulation of inflammatory responses,and promotion of tumor development and metastasis by modulating the tumor microenvironment.Macrophages differentiate from monocytes.During differentiation process,morphology and function of cells undergo significant changes.Notably,the expression of vimentin,an cytoskeletal intermediate filaments protein that is responsible for maintaining cell shape and elasticity,is found to increase drastically during macrophage differentiation.The dynamic process and molecular mechanisms underlying the upregulation of vimentin expression during macrophage differentiation,as well as the regulatory role of vimentin in the physiological and pathological functions of macrophages,remain elusive.Therefore,a deeper understanding of vimentin regulation in macrophages would help to expand its functions beyond that of a cytoskeletal protein and improve the intrinsic molecular mechanisms underlying macrophage function.This review introduces the biological functions of different forms of vimentin and the regulatory role of macrophage-expressed vimentin in the tumor microenvironment.
万方数据
维普
