Osteoarthritis is a common crippling disease.At present,drug treatment can only temporarily control inflammation and relieve pain,but can not prevent cartilage destruction in osteoarthritis.In recent years,many clinical studies have shown that mesenchymal stem cells have great potential in the treatment of osteoarthritis.It has been reported that mesenchymal stem cells and its secreted exosomes could prevent and treat osteoarthritis by regulating osteoarthritis microenvironment and/or participating in cartilage regeneration and repair,but the mechanism is still unclear,and the heterogeneity of mesenchymal stem cells and the characteristics and functions of its cell subsets are also the key scientific questions that mesenchymal stem cells needs to be answered as a therapeutic drug.This paper will review the research progress of microenvironment regulation of mesenchymal stem cells in the treatment of osteoarthritis,and put forward the scientific problems and research strategies of mesenchymal stem cells in the treatment of osteoarthritis.
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