Chemical induced pluripotent stem cells and regenerative medicine
Stem cells are cells with proliferation and differentiation potential,which can differentiate into different tissues or organs.Stem cells are an important foundation for organ regeneration and future medical development.Induced pluripotent stem cell technology can reprogram the cells at the end of differentiation into stem cells with differentiation potential.Induced pluripotent stem cells solve the ethical restrictions on the use of embryonic stem cells,and greatly expand the application of stem cells in regenerative medicine.However,the traditional reprogramming technology of introducing transcription factors(Oct4,Sox2,C-myc and Klf4)to achieve somatic cell pluripotent stem cells has limited the promotion of induced pluripotent stem cells due to its complex operation and the mutation risk of imported genes.In recent years,different research teams have realized the small molecule induced reprogramming pluripotent stem cell technology,which is easy to operate and easy to be interfered by humans,and further developed the possibility of inducing pluripotent stem cell technology to clinical application.This review summarizes the progress of compound induced reprogramming of pluripotent stem cells,especially the recent research progress of small molecule compound induced human pluripotent stem cells,and its application status and prospects in regenerative medicine.
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维普
