Regulation and mechanism of cell adhesion molecules in stem cell senescence
Stem cells have the ability of self-renewal and multi-directional differentiation potential,which play a vital role in tissue repair and homeostasis.Whereas,similar to somatic cells,stem cells suffer from cell senescence and death over time.The senescence of stem cells will further affect the overall aging of the whole body.Therefore,in-depth study of the molecular mechanism of stem cell senescence is helpful to develop effective therapeutic intervention in senescent stem cells and even the aging body.A plenty of factors have been demonstrated to affect stem cell senescence,such as miRNAs,DNA damage,loss of cell polarity,telomere shortening,and epigenetic regulation.Recently,increasing evidences show that intercellular communication is related to stem cell senescence.Cell adhesion molecules in the stem cell niche can mediate the interaction between stem cells and other cells or matrix proteins,which play an important role in maintaining stem cell niche and regulating stem cell senescence.In this paper,we have reviewed the effects of different cell adhesion molecule families(including integrin,immunoglobulin superfamily,selectin and cadherin)on the senescence of various adult stem cells,and summarized the changes and functions of extracellular matrix during stem cell senescence.We further prospect the research on the mechanism of adhesion molecules in regulating stem cell senescence and its future application.This review sheds light on exploring the new mechanism of stem cell senescence and developing anti-stem cell senescence strategies from the perspective of intercellular communication.
万方数据
维普
