Extracellular matrix microenviroment in vulnerable plaque formation
Atherosclerosis is one of the major causes of cardiovascular disease.Recent proteomics techniques have revealed the presence of more than 150 extracellular matrix components in the human vasculature,including collagen,elastic fibers,proteoglycans,glycoproteins,and matrix hydrolases,which constitute a complex extracellular matrix(ECM)microenvironment.Changes in ECM components,interactions and mechanical characteristics in plaques may affect plaque vulnerability.ECM components are also able to coordinate communication between different cell types and influence plaque progression.The role of the ECM microenvironment in atherosclerosis and related potential therapeutic strategies have been initially explored.Further exploration of the mechanisms of ECM in atherosclerosis can help dissect the pathogenesis of atherosclerosis from the perspective of the overall microenvironment and provide more effective strategies for the treatment of vulnerable plaques.In this paper,we will summarize the research related to ECM microenvironment and atherosclerotic plaque vulnerability and prospect future research directions to provide references for the treatment of vulnerable plaque from the perspective of ECM microenvironment.
万方数据
维普
