Endothelial cell secretion and matrix microenvironment
As an important part of the vasculature,endothelial cells cover the innermost layer of the heart,blood vessels and lymph vessels,which plays an important regulatory role in a variety of physiological and pathological processes,including material transport,cell proliferation,hemostasis,angiogenesis,tumorigenesis and inflammation.In addition,it can also mediate the interaction between endovascular cells and extracellular matrix microenvironment through the secretion of endothelial cells.Endothelial cells can secrete a variety of bioactive substances,which can be classified into continuous constitutive secretion and exocytosis of membranous vesicles under the regulation of multiple stimuli.Under physiological conditions,endothelial cell secretion plays a crucial role in maintaining the homeostasis of the extracellular environment,such as physiological hemostasis and angiogenesis.Under pathological conditions,endothelial cells can also respond to environmental disorders through secretion,such as damage repair and the regulation of tumor microenvironment.A comprehensive understanding of the secretory function of lymphatic vessels and blood endothelial cells and the mechanism of their regulation functions of matrix microenvironment will provide a direction for the study of their regulation of physiological functions,and lay a foundation for searching for new targets of the treatment of various diseases.
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