The interaction between cartilage-derived stem/progenitor cells and extracellular matrix during cartilage injury
Joint cartilage is a tough adhesive tissue,which has the function of reducing joint friction,buffering joint shocks and external force impact.Due to the slow proliferation of chondrocytes and poor regeneration ability,it is difficult to present an instinctive self-healing capacity after cartilage damage.Cartilage-derived stem/progenitor cells(CSPCs)exhibit a high degree of chondrogenic characteristics and hold great advantages for cartilage repair.CSPCs regard as cell source for cartilage regeneration,and extracellular matrix(ECM)provides cartilage regeneration micro-environment.In the review,we not only summarize the studies on chondrogenesis induced by CSPCs interaction with ECM,but also explore the application of ECM-related cartilage tissue engineering,providing new thought for exploring the crucial regulatory role of CSPCs interaction with extracellular matrix micro-environment in cartilage regeneration.
万方数据
维普
