The mechanism analysis of the repair and regeneration process after the occurrence of bone injury plays a fundamental and key role in the optimization and renewal of bone repair treatment methods.The various stages after bone injury involve the coordination among different cells and the precise spatiotemporal regulation of events such as inflammatory response,bone formation and bone resorption.In recent years,with the refinement of research on tissue cell populations and the in-depth study of tissue regeneration mechanisms,research on the mutual regulation among various cell types,immune cells,skeletal stem cells,and osteoblasts in the process of bone repair and regeneration has gradually increased.A variety of biomaterials serve as a bridge for the transformation of mechanism research conclusions to clinical bone repair improvement.This review discusses the research progress of bone injury repair from three aspects:the inflammatory response after bone injury,the research of skeletal stem cells in bone regeneration,and the application of materials in bone repair.
bone injury repairinflammation responseskeletal stem cellsbiomaterials
万方数据
维普
