As an important component of the hepatic vascular microenvironment,liver sinusoidal endothelial cell(LSEC)has unique phenotype and physiological effects.In recent years,more and more studies have shown that LSEC plays a key regulatory role in liver injury.Based on recent research results,this review analyzed that LSEC couid maintain the homeostasis of hepatic vascular microenvironment under normal physiological state,inhibit various liver injuries,and promote liver regeneration.Under the influence of various factors,LSEC can change its own phenotype to form capillarized LSEC,which then mediates the pathological process of hepatic fibrosis and hepatic steatosis,and also inhibits the process of liver regeneration.The analysis shows that LSEC regulates liver injury through various signaling pathways,and can be used as an important target for the treatment of liver injury and balance the hepatic vascular microenvironment.
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