Fibrosis is an important pathological and physiological event in tissue injury repair and tissue structural damage.The cellular microenvironment plays a crucial role in the process of tissue fibrosis,influencing various aspects including the interaction between the extracellular matrix and fibrogenic cells,cell-cell interactions,and the mechanical properties of the cellular microenvironment.In recent years,diverse in vitroand in vivomodels have shed light on the effect of cellular microenvironment on tissue fibrosis,revealing important insights into signaling pathways,key molecules,and biochemical processes involved.These findings have provided vital perspectives for therapeutic strategies of tissue fibrosis.Further investigation into the regulatory mechanisms of the cellular microenvironment in the fibrotic process,along with the development of new treatment strategies and innovative materials,holds great potential for the treatment and prevention of fibrotic diseases.
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