Extracellular matrix and T cell-mediated anti-tumor immune response
The expression profiles of extracellular matrix(ECM)proteins in tumor differ significantly from those in normal tissue.Aberrant deposition and remodeling of the ECM and changes in ECM physicochemical properties such as rigidity are common features of many solid tumors,and are often closely related to the therapeutic resistance.ECM can not only regulate T cell adhesion and migration,but also modulate the activation and effector function of T cells.While the ECM reshapes the tumor immune microenvironment,cytokines secreted by immune cells also regulate ECM remodeling.In recent years,combination therapy targeting the ECM and tumor immunity has attracted a lot of attention in order to control the occurrence and development of tumors.This paper summarizes the research progress of the interactive communication between the ECM and T cells in the tumor microenvironment,and the ECM-regulated anti-tumor T cell immune response.
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维普
