The biological function of integrin activating protein Talin and its role in tumor progression
Talin was first discovered in focal adhesions and lamellipodia,and it is an important component of focal adhesions.Numerous studies have confirmed that Talin is a key regulatory factor for integrin activation.It directly binds to the cytoplasmic segment of integrin and mediates its activation,while also binding to actin filaments in the cytoplasm.Talin is a crucial protein for cells to sense mechanical force.As a bridge connecting the cell skeleton and the transmembrane receptor integrin,Talin plays a critical role in regulating fundamental processes such as cell adhesion,movement,and migration,and plays an important role in the development of diseases such as tumors.This review will discuss the structure,cellular function,and post-translational modification(PTM)of Talin,as well as its role in the occurrence and development of diseases.
万方数据
维普
