Talin was first discovered in focal adhesions and lamellipodia,and it is an important component of focal adhesions.Numerous studies have confirmed that Talin is a key regulatory factor for integrin activation.It directly binds to the cytoplasmic segment of integrin and mediates its activation,while also binding to actin filaments in the cytoplasm.Talin is a crucial protein for cells to sense mechanical force.As a bridge connecting the cell skeleton and the transmembrane receptor integrin,Talin plays a critical role in regulating fundamental processes such as cell adhesion,movement,and migration,and plays an important role in the development of diseases such as tumors.This review will discuss the structure,cellular function,and post-translational modification(PTM)of Talin,as well as its role in the occurrence and development of diseases.
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