Role of extracellular matrix protein periostin in tumor microenvironments
Periostin is a non-structural extracellular matrix protein that plays an important role in tissue damage repair,tissue regeneration,fibrosis,and tumor development.Recent studies have demonstrated that periostin serves as a critical tumor microenvironmental factor in promoting the activation of stromal cells,recruiting immune cells and regulating their functions,remodeling tissue microenvironment,and facilitating tumor cell growth and metastasis.Here we summarize the functions of extracellular matrix protein periostin in various tumor microenvironments,such as tumor metastatic niche,cancer stem cell niche,perivascular niche,premetastatic niche,tumor immune microenvironment,fibrotic microenvironment,bone marrow microenvir-onment,and invasion front niche.We also highlight that periostin is crucial for tumor microenvironment by regulating the interactions between cells and extracellular matrix,between tumor cells and stromal cells,and between different extracellular matrix proteins.
万方数据
维普
