Cellular senescence refers to the phenomenon of significant changes in cell morphology and physiological functions after the limited subdivision of normal cells.Senescence-associated secretory phenotype(SASP)is a typical characteristic of cellular senescence,which coordinates intercellular function,controls cell growth,division,and aging via intercellular communication,thereby affecting tissue,organ,individual aging,and related diseases.In this review,we will discuss the mechanism of intercellular communication on cellular senescence,expounding its influence on individual aging and diseases,and looks forward to the intervention of intercellular communication in cellular senescence and aging related diseases.
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