Heme oxygenase-1 as a potential plasma and saliva biomarker of Parkinson's disease
Parkinson's disease is a common neurodegenerative disease among the elderly in the world.At present,there is no effective cure method in clinic.Its clinical manifestations are various and the accuracy of early diagnosis is low.Therefore,it is urgent to find and study appropriate biomarkers for early diagnosis and monitoring of disease progress.Plasma and saliva are considered to be good sample sources for the detection of disease biomarkers,with the advantages of being reusable,cheap and easy to obtain.The level of heme oxygenase-1 in plasma and saliva of patients increases with early Parkinson's disease and fluctuates with the disease status.Here,we will briefly describe the research on the correlation and specificity between the expression level of HO-1 in plasma and saliva and the disease progression stage,hippocampus volume,iron deposition,hemoglobin level and saliva secretion,in order to explore the potential of HO-1 in plasma and saliva as a biomarker of Parkinson's disease for early diagnosis and intervention.
万方数据
维普
