Prevention and treatment of non-steroidal anti-inflammatory drug related gastric ulcer
Non-steroidal anti-inflammatory drugs(NSAIDs)are widely used in clinical practice,and their adverse reactions are mainly the occurrence of gastric ulcer.Clinical use of NSAIDs physicians should understand the comprehensive prevention and treatment of NSAIDS-related gastric ulcers,including diet,lifestyle adjustment,timely eradication of Helicobacter pylori(Hp),education,individualized selection of medication according to individual risk factors and functional monitoring.Drugs rather than invasive procedures or surgery are the main treatment options.At present,anti-ulcer drugs mainly include acid suppressors,mucosal protectants,prostaglandin analogues,etc.,but there is no authoritative guideline for specific compatibility selection and dosage in China.In order to comprehensively understand the occurrence of NSAIDS-related gastric ulcers,this paper intends to review the factors and mechanism of peptic ulcer and mucosal injury in NSAIDs users,prevention strategies of NSAIDS-related gastric ulcers,therapeutic measures of related drugs,current application status of NSAIDs and future prospects
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