Parkinson's disease(PD)is the second most common neurodegenerative disorder worldwide.The degeneration of dopaminergic neurons under oxidative stress is the pathological basis of movement disorders.Astrocytes can regulate dopamine and glutamate conduction by secreting a variety of factors to regulate tripartite synapse,and can secrete pro-inflammatory factors to participate in the pathological process of PD.Exercise can regulate astrocytes of anti-oxidative stress,reducing neurotoxicity and inflammatory response,and improve PD performance by neuroprotection.In this paper,we highlight astrocyte-neurons bidirectional interaction,review the pathogenic and neuroprotective role of astrocytes in PD and exercise intervention,thus provide theoretical reference for further understanding the astrocyte-mediated neuroprotection in PD.
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