Research progress of exercise-regulated astrocytes in ameliorating Parkinson's disease
Parkinson's disease(PD)is the second most common neurodegenerative disorder worldwide.The degeneration of dopaminergic neurons under oxidative stress is the pathological basis of movement disorders.Astrocytes can regulate dopamine and glutamate conduction by secreting a variety of factors to regulate tripartite synapse,and can secrete pro-inflammatory factors to participate in the pathological process of PD.Exercise can regulate astrocytes of anti-oxidative stress,reducing neurotoxicity and inflammatory response,and improve PD performance by neuroprotection.In this paper,we highlight astrocyte-neurons bidirectional interaction,review the pathogenic and neuroprotective role of astrocytes in PD and exercise intervention,thus provide theoretical reference for further understanding the astrocyte-mediated neuroprotection in PD.
万方数据
维普
