Ferritinophagy is a new type of autophagy,playing an important role in maintaining iron homeostasis in cells.In the process of ferritinophagy,a complex composed of nuclear receptor coactivator 4 and ferritin is fused with the autophagosome and targeted lysosomes to degrade ferritin to release free iron for body use.Ferritinophagy is also an important part of ferroptosis.When ferritinophagy is over activated,it can lead to intracellular iron overload and accumulation of lethal reactive oxygen species in cells,resulting in a large number of cell ferroptosis.Ferritinophagy has become a upstream mechanism inducing ferroptosis by regulating intracellular iron homeostasis and the generation of lethal reactive oxygen species,which is closely related to the occurrence and development of cerebral ischemia reperfusion injury,cancer,cardiovascular system and other diseases.Therefore,to study the functional characteristics of nuclear receptor coactivator 4 mediated ferritinophagy pathway in ferroptosis,and to understand the role of ferritinophagy mechanism in the development direction of different diseases,may provide implications for the treatment of ferritinophagy related diseases.This paper will discuss the pathway of ferritinophagy from the aspects of the mechanism and regulatory factors of ferritinophagy,the relationship between ferritinophagy and ferroptosis,and focus on the role of ferritinophagy in the occurrence and development of different diseases,hoping to provide new ideas for the treatment of related diseases by taking ferritinophagy as the starting point.
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