Research progress of epigenetic modification regulating asthma occurrence
Asthma is a kind of heterogeneous chronic airway inflammation involving multiple cells.It has seriously threatened human health and life because of the high incidence,recurrent illness and a long course of the disease.Its pathogenesis is complex and has not yet been elucidated.In recent years,epigenetics,as a mechanism of regulating gene changes through epigenetic modification,by which mediated the gene regulation process is closely related to the complex pathophysiological changes of asthma,and is one of the mechanisms affecting the pathogenesis and heterogeneity of asthma.Therefore,this paper reviews advanced research progress in the regulation of asthma through three main ways of epigenetic modification—DNA methylation,histone modification,and the mechanism progress of microRNA in the occurrence and development of asthma,in order to clarify a new epigenetic regulation mechanism of asthma,and provide clues for the discovery of new asthma biomarker and a new therapeutic target for the treatment of asthma.
万方数据
维普
