首页|光动力疗法在宫颈癌治疗中的作用

光动力疗法在宫颈癌治疗中的作用

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宫颈癌是全世界范围内常见致死癌症之一,目前宫颈癌治疗以手术联合放化疗为主,手术治疗带来的生育风险、身体创伤、心理负担及放化疗产生的副作用严重影响着患者的身心健康,因此不得不探索更好更有效的抗肿瘤方法.光动力疗法(photodynamic therapy,PDT)是目前肿瘤辅助手段之一,具有侵袭性小、低副作用、时空选择性高等优点,是一种治疗宫颈癌的理想替代方案.目前对于PDT治疗宫颈癌的研究逐渐兴起,在光敏剂、联合治疗、纳米材料领域成果显著,体外实验中PDT显示出显著的抗宫颈癌肿瘤细胞作用.从体外走向体内实验,克服宫颈癌相比体表肿瘤发病位置特殊的困难,寻找合适的用于PDT临床治疗宫颈癌的方案是目前研究的关键,PDT作为一种优势治疗手段,用于治疗宫颈癌前景广阔.本文针对目前宫颈癌的治疗现状、PDT治疗肿瘤的优势、PDT用于治疗宫颈癌的研究现状进行阐述,强调了纳米材料在PDT治疗宫颈癌中的重要性,旨在为PDT治疗宫颈癌提供新方向和策略.
The role of photodynamic therapy in the treatment of cervical cancer
Cervical cancer is one of the common fatal cancers worldwide.Currently,the treatment of cervical cancer is mainly surgery combined with radiotherapy and chemotherapy.The reproductive risks,physical trauma,psychological burden,and side effects of radiotherapy and chemotherapy caused by surgical treatment seriously affect the physical and mental health of patients,so it is necessary to explore better and more effective anti-tumor methods.Photodynamic therapy(PDT)is one of the current adjuvant methods for cancer,with the advantages of low invasion,low side effects,and high spatiotemporal selectivity.It is an ideal alternative for the treatment of cervical cancer.At present,research on the treatment of cervical cancer with PDT is gradually emerging,with significant achievements in the fields of photosensitizers,combination therapy,and nanomaterials.PDT has shown significant anti cervical cancer tumor cell effects in vitro experiments.From in vitro to in vivo experiments,overcoming the difficulties of the special location of cervical cancer compared to surface tumors,and finding suitable PS or nanomaterial solutions for PDT clinical treatment of cervical cancer are currently the key to research.As an advantageous treatment method,PDT has broad prospects use in the treatment of cervical cancer.This review elaborates on the current treatment status of cervical cancer,the advantages of PDT in treating tumors,and the research status of PDT in treating cervical cancer.It emphasizes the importance of nanomaterials in PDT treatment of cervical cancer,aiming to provide new directions and strategies for PDT treatment of cervical cancer.

cervical cancerphotodynamic therapyphotosensitizercombination therapynanometer material

王翮、平毅

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山西医科大学第二医院妇产科,太原 030000

宫颈癌 光动力疗法 光敏剂 联合疗法 纳米材料

山西省科技厅重点攻关专项

2022XM23

2023

生命的化学
中国生物化学与分子生物学会

生命的化学

CSTPCD
影响因子:0.404
ISSN:1000-1336
年,卷(期):2023.43(8)
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