Research progress on Twist and its regulators and human gastric cancer invasion and metastasis
Gastric cancer(GC)is a severe malignant tumor that poses a significant threat to human health and life.Recent studies have revealed the crucial role of the Twist gene in promoting tumor formation,primarily through the regulation of gene expression and epithelial-mesenchymal transition(EMT).Previous research has demonstrated that Twist promoted EMT occurrence in gastric cancer.However,the mechanisms underlying Twist and its regulatory factors in EMT initiation,as well as the role of Twist-induced EMT in tumor metastasis,remain incompletely understood.This paper aims to comprehensively present the role of the Twist gene and its regulatory factors in the progression of gastric cancer,reviewing relevant research advances and providing unique academic perspectives and predicted development directions.Through in-depth analysis and exploration,this paper will offer valuable guidance and suggestions for further understanding the mechanisms of gastric cancer occurrence and the development of effective therapeutic strategies,while adhering to the language characteristics of scientific papers.
万方数据
维普
