The mechanism of AURKA regulation of tumor cisplatin resistance
Cisplatin is widely used as a first-line chemotherapeutic drug in a variety of tumors.The emergence of its drug resistance has brought great difficulties to clinical diagnosis and treatment.It is necessary to explore new mechanisms to improve drug resistance and efficacy.Recent studies have shown that aurora kinase A(AURKA)is closely related to the malignant behavior of tumors and can regulate the resistance mechanism of cisplatin.AURKA not only induces cisplatin resistance by inhibiting apoptosis,but also induces cisplatin resistance by inducing autophagy,epithelial-mesenchymal transition,and regulating cellular glucose metabolism.Targeted regulation of AURKA has the potential to reverse cisplatin resistance.This paper hopes to provide a more reliable theoretical basis for targeting AURKA to reverse cisplatin resistance through a more comprehensive elaboration of the mechanism by which AURKA regulates cisplatin resistance.
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