Research progress on the regulatory mechanism of exosomal circRNA related signaling pathways in gastric cancer and traditional Chinese medicine intervention
Gastric cancer(GC)is the highest incidence of digestive tract tumor in China.In recent years,the 5-year overall survival rate of patients with GC is less than 30%,which seriously endangers the quality of life of patients.With the development of bioinformatics methods,different types of exosomal circular RNA(circRNA)have been identified to act on a specific target to regulate the expression level of related signaling molecules,which can activate or inhibit some signal pathways to participate in the development of GC.Traditional Chinese medicine(TCM)can precisely regulate the related signal pathways and key molecular expressions based on the advantages of multiple targets and pathways,achieving the effect of preventing and treating GC.Currently,the regulatory mechanisms of exosomal circRNA in GC have become research hotspots.In this paper,the progress of exosomal circRNA molecules and related signal pathways in regulating GC in recent years and the specific mechanisms of Chinese medicine intervening in signal pathways are reviewed in order to provide new ideas for the prevention and treatment of GC with TCM.
万方数据
维普
